Cxcr5^tm1Lipp
Targeted Allele Detail

Summary

• Symbol: Cxcr5^tm1Lipp
• Name: C-X-C motif chemokine receptor 5; targeted mutation 1, Martin Lipp
• MGI ID: MGI:2158677
• Synonyms: Blr1^-, CXCR5-
• Gene: Cxcr5 Location: Chr9:44423084-44437741 bp, - strand Genetic Position: Chr9, 24.84 cM
• Alliance: Cxcr5^tm1Lipp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:37126
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette was inserted into exon 2. Northern blot analysis on RNA derived from spleen cells of homozygous mice demonstrated that no detectable transcipt was produced from this allele (data not shown), and flow cytometry experiments on leukocytes derived from homozygous mice demonstrated that no detectable protein was produced. (J:37126)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Cxcr5 Mutation: 28 strains or lines available

References

• Original: J:37126 Forster R, et al., A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell. 1996 Dec 13;87(6):1037-47
• All: 91 reference(s)