C3ar1^tm1Cge
Targeted Allele Detail

Summary

• Symbol: C3ar1^tm1Cge
• Name: complement component 3a receptor 1; targeted mutation 1, Craig Gerard
• MGI ID: MGI:2158678
• Synonyms: C3aR -
• Gene: C3ar1 Location: Chr6:122824099-122833116 bp, - strand Genetic Position: Chr6, 57.93 cM, cytoband F1
• Alliance: C3ar1^tm1Cge page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64378
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 736 bp DNA fragment containing the translation start site and coding sequences for the N-terminal part of the protein was replaced with a neomycin selection cassette. RT-PCR analysis on RNA derived from bone marrow cells of homozygous mice confirmed that no detectable transcript is produced from this allele. (J:64378)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any C3ar1 Mutation: 36 strains or lines available

References

• Original: J:64378 Humbles AA, et al., A role for the C3a anaphylatoxin receptor in the effector phase of asthma. Nature. 2000 Aug 31;406(6799):998-1001
• All: 74 reference(s)