Irs2^tm1Mfw
Targeted Allele Detail

Summary

• Symbol: Irs2^tm1Mfw
• Name: insulin receptor substrate 2; targeted mutation 1, Morris F White
• MGI ID: MGI:2158686
• Synonyms: Irs2^-
• Gene: Irs2 Location: Chr8:11034681-11058458 bp, - strand Genetic Position: Chr8, 5.35 cM
• Alliance: Irs2^tm1Mfw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46134
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector containing a PGK-neomycin cassette replaced the entire gene. Lack of protein was demonstrated in liver and muscle extracts by Western analysis in homozygous mutant animals. (J:46134)

Disease models

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	13 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Irs2^tm1Mfw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Irs2 Mutation: 37 strains or lines available

References

• Original: J:46134 Withers DJ, et al., Disruption of IRS-2 causes type 2 diabetes in mice. Nature. 1998 Feb 26;391(6670):900-4
• All: 61 reference(s)