Rara^tm1Rev
Targeted Allele Detail

Summary

• Symbol: Rara^tm1Rev
• Name: retinoic acid receptor, alpha; targeted mutation 1, Ronald M Evans
• MGI ID: MGI:2158687
• Synonyms: Rara1 null, RARalpha1 -
• Gene: Rara Location: Chr11:98818644-98865768 bp, + strand Genetic Position: Chr11, 62.76 cM, cytoband D-E1
• Alliance: Rara^tm1Rev page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:3997
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A DNA fragment containing a portion of the coding sequence downstream of the sixth codon was replaced with a neomycin selection cassette. Northern blot and RT-PCR analysis on skin, muscle and liver samples of homozygous mice demonstrated that no detectable transcript is produced from this allele. (J:3997)

Expression

In Mice Carrying this Mutation:

10 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rara Mutation: 79 strains or lines available

References

• Original: J:3997 Li E, et al., Normal development and growth of mice carrying a targeted disruption of the alpha 1 retinoic acid receptor gene. Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1590-4
• All: 10 reference(s)