Npy1r^tm1Aka
Targeted Allele Detail

Summary

• Symbol: Npy1r^tm1Aka
• Name: neuropeptide Y receptor Y1; targeted mutation 1, Akio Kanatani
• MGI ID: MGI:2158689
• Gene: Npy1r Location: Chr8:67149844-67159444 bp, + strand Genetic Position: Chr8, 33.15 cM, cytoband B3-C2
• Alliance: Npy1r^tm1Aka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60632
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted using neomycin resistance cassette. The vector replaced both exons 1 and 2. Northern analysis failed to detect transcript in homozygous mutant animals. (J:60632)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npy1r Mutation: 25 strains or lines available

References

• Original: J:60632 Kanatani A, et al., Role of the Y1 receptor in the regulation of neuropeptide Y-mediated feeding: comparison of wild-type, Y1 receptor-deficient, and Y5 receptor-deficient mice. Endocrinology. 2000 Mar;141(3):1011-6
• All: 1 reference(s)