Rarb^tm1Vgi
Targeted Allele Detail

Summary

• Symbol: Rarb^tm1Vgi
• Name: retinoic acid receptor, beta; targeted mutation 1, Vincent Giguere
• MGI ID: MGI:2158691
• Synonyms: RARbeta-
• Gene: Rarb Location: Chr14:5650540-6038924 bp, + strand Genetic Position: Chr14, 7.08 cM, cytoband A1-A3
• Alliance: Rarb^tm1Vgi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29061
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing sequences encoding the first zinc finger motif was replaced with a neomycin selection cassette. This region encodes an essential portion of the protein common to all encoded isoforms. Northern blot analysis on RNA derived from E13.5 homozygous embryos demonstrated that no detectable transcript is produced from this allele. (J:29061)

Expression

In Mice Carrying this Mutation:	64 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rarb Mutation: 40 strains or lines available

References

• Original: J:29061 Luo J, et al., Mice lacking all isoforms of retinoic acid receptor beta develop normally and are susceptible to the teratogenic effects of retinoic acid. Mech Dev. 1995 Sep;53(1):61-71
• All: 13 reference(s)