Rorb^tm1Mba
Targeted Allele Detail

Summary

• Symbol: Rorb^tm1Mba
• Name: RAR-related orphan receptor beta; targeted mutation 1, Michael Becker-Andre
• MGI ID: MGI:2158692
• Synonyms: RORbeta -
• Gene: Rorb Location: Chr19:18907969-19088560 bp, - strand Genetic Position: Chr19, 13.28 cM
• Alliance: Rorb^tm1Mba page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48923
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ gene followed by a neomycin selection cassette was inserted in frame into the sequences encoding the second zinc finger. A RORB-beta-galactosidase fusion protein is expressed from this allele under the control of the endogenous promoter. (J:48923)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rorb Mutation: 41 strains or lines available

References

• Original: J:48923 Andre E, et al., Disruption of retinoid-related orphan receptor beta changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice. EMBO J. 1998 Jul 15;17(14):3867-77
• All: 6 reference(s)