Camk4^tm1Arm
Targeted Allele Detail

Summary

• Symbol: Camk4^tm1Arm
• Name: calcium/calmodulin-dependent protein kinase IV; targeted mutation 1, Anthony R Means
• MGI ID: MGI:2158694
• Gene: Camk4 Location: Chr18:33067984-33324281 bp, + strand Genetic Position: Chr18, 18.15 cM
• Alliance: Camk4^tm1Arm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70570
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing the first two exons was replaced with a neomycin selection cassette. Western blot analysis on brain extracts derived from homozygous mice demonstrated that no detectable protein is produced from this allele. (J:70570)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Camk4 Mutation: 39 strains or lines available

References

• Original: J:70570 Wu JY, et al., Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4. Nat Genet. 2000 Aug;25(4):448-52
• All: 11 reference(s)