Men1^tm1Ctre
Targeted Allele Detail

Summary

• Symbol: Men1^tm1Ctre
• Name: multiple endocrine neoplasia 1; targeted mutation 1, Judy S Crabtree
• MGI ID: MGI:2158697
• Synonyms: Men1^l, Men1^loxP, Men1^TSM
• Gene: Men1 Location: Chr19:6385009-6390921 bp, + strand Genetic Position: Chr19, 4.45 cM, cytoband A
• Alliance: Men1^tm1Ctre page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67128
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout)
• Mutation: Insertion
• Mutation details: A loxP-flanked neomycin selection cassette was inserted into intron 2 and a third loxP site was inserted into intron 8. (J:67128)

Disease models

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Men1^tm1Ctre

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Men1 Mutation: 40 strains or lines available

References

• Original: J:67128 Crabtree JS, et al., A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors. Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1118-23
• All: 25 reference(s)