Men1^tm1.1Ctre
Targeted Allele Detail

Summary

• Symbol: Men1^tm1.1Ctre
• Name: multiple endocrine neoplasia 1; targeted mutation 1.1, Judy S Crabtree
• MGI ID: MGI:2158698
• Synonyms: dN3-8, Men1^-, Men1^deltaN3-8, Men1delta^N3-8
• Gene: Men1 Location: Chr19:6385009-6390921 bp, + strand Genetic Position: Chr19, 4.45 cM, cytoband A
• Alliance: Men1^tm1.1Ctre page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67128
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele is a derivative of Men1^tm1Ctre in which the neomycin cassette and exons 3-8 of the gene were removed by Cre mediated recombination by crossing mice carrying the Men^tm1Ctre allele to mice expressing Cre recombinase under the control of a ubiquitous promoter. (J:67128)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Men1^tm1.1Ctre

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Men1 Mutation: 40 strains or lines available

References

• Original: J:67128 Crabtree JS, et al., A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors. Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1118-23
• All: 19 reference(s)