Npy1r^tm1Tped
Targeted Allele Detail

Summary

• Symbol: Npy1r^tm1Tped
• Name: neuropeptide Y receptor Y1; targeted mutation 1, Thierry Pedrazzini
• MGI ID: MGI:2158699
• Synonyms: NPY-, Npyr1^-, Y1-
• Gene: Npy1r Location: Chr8:67149844-67159444 bp, + strand Genetic Position: Chr8, 33.15 cM, cytoband B3-C2
• Alliance: Npy1r^tm1Tped page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47972
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaces most of the second exon encoding the fifth transmembrane domain and a part of the interrupting intron. (J:47972)

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npy1r Mutation: 25 strains or lines available

References

• Original: J:47972 Pedrazzini T, et al., Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor [see comments]. Nat Med. 1998 Jun;4(6):722-6
• All: 12 reference(s)