Scnn1a^tm1Rss
Targeted Allele Detail

Summary

• Symbol: Scnn1a^tm1Rss
• Name: sodium channel, nonvoltage-gated 1 alpha; targeted mutation 1, Bernard C Rossier
• MGI ID: MGI:2158700
• Synonyms: alphaENaC -, Scnn1a^tm1
• Gene: Scnn1a Location: Chr6:125297622-125321906 bp, + strand Genetic Position: Chr6, 59.32 cM
• Alliance: Scnn1a^tm1Rss page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:31762
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing part of exon 1 and sequences encoding the first transmembrane loop and most of the ectocytoplasmic loop was replaced with a neomycin selection cassette. RT-PCR analysis on samples derived from lung, liver and kidney tissue of homozygous mice confirmed that no detectable transcript is produced from this allele. (J:31762)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Scnn1a Mutation: 28 strains or lines available

References

• Original: J:31762 Hummler E, et al., Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice. Nat Genet. 1996 Mar;12(3):325-8
• All: 13 reference(s)