C1qa^tm1Mjw
Targeted Allele Detail

Summary

• Symbol: C1qa^tm1Mjw
• Name: complement component 1, q subcomponent, alpha polypeptide; targeted mutation 1, Mark J Walport
• MGI ID: MGI:2158701
• Synonyms: C1q-, C1qa-, C1qa^tm1Barr
• Gene: C1qa Location: Chr4:136623228-136626114 bp, - strand Genetic Position: Chr4, 69.05 cM
• Alliance: C1qa^tm1Mjw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47315
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 1 of the gene. Northern blot analysis on samples derived from spleen and liver of homozygous mice demonstrated that no transcript is produced from this allele. Western blot and ELISA analysis confirmed that no protein was detected in samples derived from homozygous mice. (J:47315, J:194445)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any C1qa Mutation: 24 strains or lines available

References

• Original: J:47315 Botto M, et al., Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies [see comments]. Nat Genet. 1998 May;19(1):56-9
• All: 150 reference(s)