Npy1r^tm1Mnak
Targeted Allele Detail

Summary

• Symbol: Npy1r^tm1Mnak
• Name: neuropeptide Y receptor Y1; targeted mutation 1, Motonao Nakamura
• MGI ID: MGI:2158702
• Gene: Npy1r Location: Chr8:67149844-67159444 bp, + strand Genetic Position: Chr8, 33.15 cM, cytoband B3-C2
• Alliance: Npy1r^tm1Mnak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51684
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exons 2 and 3 are replaced with a neomycin resistance cassette. Northern blot analysis from brain confirmed the absence of transcript in homozygous mutant animals. The Y5 receptor, which resides in close proximity to the Y1 receptor, was unaffected by the gene targeting, as demonstrated by Northern analysis. (J:51684)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npy1r Mutation: 25 strains or lines available

References

• Original: J:51684 Kushi A, et al., Obesity and mild hyperinsulinemia found in neuropeptide Y-Y1 receptor-deficient mice. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15659-64
• All: 1 reference(s)