C3^tm1Hrc
Targeted Allele Detail

Summary

• Symbol: C3^tm1Hrc
• Name: complement component 3; targeted mutation 1, Harvey R Colten
• MGI ID: MGI:2158703
• Synonyms: C3-
• Gene: C3 Location: Chr17:57510970-57535136 bp, - strand Genetic Position: Chr17, 29.72 cM, cytoband E1-E3
• Alliance: C3^tm1Hrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88308
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing 2.3 kb of the 5' flanking region and the first 105 bp of exon 1 was replaced with a neomycin selection cassette. Northern blot analysis on liver RNA derived from homozygous mice demonstrated that no detectable transcript was produced in this tissue; however, a full length transcript was detected in lung, kidney, epididymal fat tissue, spleen and heart. (J:56193, J:98856)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any C3 Mutation: 103 strains or lines available

Notes

ES cell line = RW4 (129X1/SvJ) or D3 (129S2/SvPas).

References

• Original: J:88308 Lubinski JM, et al., Herpes simplex virus type 1 glycoprotein gC mediates immune evasion in vivo. J Virol. 1998 Oct;72(10):8257-63
• All: 81 reference(s)