Ciita^tm1Jpyt
Targeted Allele Detail

Summary

• Symbol: Ciita^tm1Jpyt
• Name: class II transactivator; targeted mutation 1, Jenny P Y Ting
• MGI ID: MGI:2158705
• Synonyms: CIITA -, CIITA G^-
• Gene: Ciita Location: Chr16:10297923-10346282 bp, + strand Genetic Position: Chr16, 5.65 cM, cytoband B1
• Alliance: Ciita^tm1Jpyt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57100
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3.0 kb genomic fragment containing sequences encoding the GTP-binding domain was replaced with a neomycin selection cassette. RT-PCR analysis on samples derived from spleen, thymus and lymph nodes from homozygous mice demonstrated that no detectable transcript was produced from this allele. (J:57100)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ciita Mutation: 46 strains or lines available

References

• Original: J:57100 Itoh-Lindstrom Y, et al., Reduced IL-4-, lipopolysaccharide-, and IFN-gamma-induced MHC class II expression in mice lacking class II transactivator due to targeted deletion of the GTP-binding domain. J Immunol. 1999 Sep 1;163(5):2425-31
• All: 6 reference(s)