Gli2^{tm3.1(Gli1)Alj}
Targeted Allele Detail

Summary

• Symbol: Gli2^{tm3.1(Gli1)Alj}
• Name: GLI-Kruppel family member GLI2; targeted mutation 3.1, Alexandra L Joyner
• MGI ID: MGI:2158720
• Synonyms: Gli2^1ki
• Gene: Gli2 Location: Chr1:118761862-118981349 bp, - strand Genetic Position: Chr1, 52.17 cM, cytoband E2-E4
• Alliance: Gli2^{tm3.1(Gli1)Alj} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73074
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A mouse Gli cDNA and a loxP-flanked neomycin selection cassette replaced 56 bp of exon 2, including the initiation codon. The neomycin selection cassette was removed by Cre mediated recombination in mice by crossing Gli2^tm3Alj mice with NLS-cre expressing mice, and selecting for offspring that no longer had the neomycin cassette. (J:73074)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gli2 Mutation: 169 strains or lines available

References

• Original: J:73074 Bai CB, et al., Gli1 can rescue the in vivo function of Gli2. Development. 2001 Dec;128(24):5161-72
• All: 5 reference(s)