Tgfbr2^tm1Mmt
Targeted Allele Detail

Summary

• Symbol: Tgfbr2^tm1Mmt
• Name: transforming growth factor, beta receptor II; targeted mutation 1, Makoto M Taketo
• MGI ID: MGI:2158728
• Gene: Tgfbr2 Location: Chr9:115916763-116004431 bp, - strand Genetic Position: Chr9, 68.39 cM
• Alliance: Tgfbr2^tm1Mmt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73414
• Parent Cell Line: D3a2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 4 at the sequence corresponding to codon 230. RT-PCR analysis on RNA derived from targeted ES cells demonstrated that no wild-type transcript was produced from this allele. (J:73414)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tgfbr2 Mutation: 40 strains or lines available

Notes

Chimeric mice exhibit a wasting phenotype with severe weight loss within 2 weeks. Chimeras show various phenotypes, from small organ size, to cystic kidney and internal hydrcephalus with internal hemorrhage in the brain, or agnathia with anophthalmia and synotia (J:73414).

References

• Original: J:73414 Oshima M, et al., TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis. Dev Biol. 1996 Oct 10;179(1):297-302
• All: 7 reference(s)