Nodal^tm1Mku
Targeted Allele Detail

Summary

• Symbol: Nodal^tm1Mku
• Name: nodal growth differentiation factor; targeted mutation 1, Michael R Kuehn
• MGI ID: MGI:2158730
• Synonyms: nodal^fl1
• Gene: Nodal Location: Chr10:61253751-61261117 bp, + strand Genetic Position: Chr10, 32.21 cM
• Alliance: Nodal^tm1Mku page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73506
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph, Reporter)
• Mutation: Insertion
• Mutation details: This floxed allele was generated by insertion of the IRES beta-geo cassette directly after the stop codon in the 3rd exon. LoxP sites were inserted in the 1st intron and after the 3'UTR. The allele was assessed as a hypomorph. (J:73506)

Expression

In Mice Carrying this Mutation:	94 assay results
In Structures Affected by this Mutation:	14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nodal Mutation: 42 strains or lines available

References

• Original: J:73506 Lowe LA, et al., Genetic dissection of nodal function in patterning the mouse embryo. Development. 2001 May;128(10):1831-43
• All: 7 reference(s)