Tgfb3^tm1Jhg
Targeted Allele Detail

Summary

• Symbol: Tgfb3^tm1Jhg
• Name: transforming growth factor, beta 3; targeted mutation 1, John H Groffen
• MGI ID: MGI:2158731
• Synonyms: TGF-beta3-
• Gene: Tgfb3 Location: Chr12:86103519-86125815 bp, - strand Genetic Position: Chr12, 40.09 cM
• Alliance: Tgfb3^tm1Jhg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29902
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 6. RT-PCR analysis on total head RNA of newborn homozygous pups demonstrated that no detectable transcript is produced from this allele. (J:29902)

Expression

In Mice Carrying this Mutation:	30 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tgfb3 Mutation: 35 strains or lines available

References

• Original: J:29902 Kaartinen V, et al., Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction. Nat Genet. 1995 Dec;11(4):415-21
• All: 9 reference(s)