Nodal^tm1.1Mku
Targeted Allele Detail

Summary

• Symbol: Nodal^tm1.1Mku
• Name: nodal growth differentiation factor; targeted mutation 1.1, Michael R Kuehn
• MGI ID: MGI:2158732
• Synonyms: Nodal-, Nodal^Delta
• Gene: Nodal Location: Chr10:61253751-61261117 bp, + strand Genetic Position: Chr10, 32.21 cM
• Alliance: Nodal^tm1.1Mku page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73506
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele is a derivative of Nodal^tm1Mku. Cre mediated recombination was achieved by crossing Nodal^tm1Mku mice with transgenic mice expressing Cre under the control of the EIIa promoter. The recombination effectively removed the IRES beta-geo cassette, part of the 1st intron, the 2nd and 3rd exons, the 2nd intron and the 3'UTR of the Nodal gene. (J:73506)

Expression

In Mice Carrying this Mutation:	59 assay results
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nodal Mutation: 42 strains or lines available

References

• Original: J:73506 Lowe LA, et al., Genetic dissection of nodal function in patterning the mouse embryo. Development. 2001 May;128(10):1831-43
• All: 7 reference(s)