Neurod4^tm1Kag
Targeted Allele Detail

Summary

• Symbol: Neurod4^tm1Kag
• Name: neurogenic differentiation 4; targeted mutation 1, Ryoichiro Kageyama
• MGI ID: MGI:2158737
• Synonyms: Math3^-, Neurod4^tm1Rka
• Gene: Neurod4 Location: Chr10:130104021-130116109 bp, - strand Genetic Position: Chr10, 77.81 cM
• Alliance: Neurod4^tm1Kag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65410
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette is inserted into the second exon of the wild-type gene. Northern analysis demonstrated a lack of gene specific mRNA in homozygous mutant animals. (J:65410)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Neurod4 Mutation: 24 strains or lines available

References

• Original: J:65410 Tomita K, et al., Mammalian achaete-scute and atonal homologs regulate neuronal versus glial fate determination in the central nervous system. EMBO J. 2000 Oct 16;19(20):5460-72
• All: 8 reference(s)