Casp9^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Casp9^tm1Mak
• Name: caspase 9; targeted mutation 1, Tak W Mak
• MGI ID: MGI:2158754
• Gene: Casp9 Location: Chr4:141520923-141543287 bp, + strand Genetic Position: Chr4, 74.75 cM, cytoband E1
• Alliance: Casp9^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49087
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2.6 kb genomic fragment containing three exons was replaced with a neomycin selection cassette. The deleted sequences encode motifs required for protein activity. (J:49087)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Casp9 Mutation: 20 strains or lines available

References

• Original: J:49087 Hakem R, et al., Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell. 1998 Aug 7;94(3):339-52
• All: 5 reference(s)