Casp9^tm1Flv
Targeted Allele Detail

Summary

• Symbol: Casp9^tm1Flv
• Name: caspase 9; targeted mutation 1, Richard A Flavell
• MGI ID: MGI:2158755
• Synonyms: caspase 9^-, caspase-9-
• Gene: Casp9 Location: Chr4:141520923-141543287 bp, + strand Genetic Position: Chr4, 74.75 cM, cytoband E1
• Alliance: Casp9^tm1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49088
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1 kb genomic fragment containing sequences encoding a motif essential for protein activity was replaced with a neomycin selection cassette. RT-PCR analysis on RNA derived from kidney of homozygous mice demonstrated that no detectable transcript was produced from this allele. (J:49088)

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Casp9 Mutation: 20 strains or lines available

References

• Original: J:49088 Kuida K, et al., Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell. 1998 Aug 7;94(3):325-37
• All: 32 reference(s)