Calb2^tm1Map
Targeted Allele Detail

Summary

• Symbol: Calb2^tm1Map
• Name: calbindin 2; targeted mutation 1, Marc Parmentier
• MGI ID: MGI:2158756
• Synonyms: Cr -
• Gene: Calb2 Location: Chr8:110869158-110894844 bp, - strand Genetic Position: Chr8, 57.44 cM
• Alliance: Calb2^tm1Map page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42924
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced 31 bp of the second exon. Northern blot analysis on brain samples derived from homozygous mice demonstrated that no detectable transcript was produced from this allele. Western blot analysis on brain and ocular globe samples derived from homozygous mice confirmed that no detectable protein was made. (J:42924)

Expression

In Mice Carrying this Mutation:

1 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Calb2 Mutation: 23 strains or lines available

References

• Original: J:42924 Schurmans S, et al., Impaired long-term potentiation induction in dentate gyrus of calretinin-deficient mice. Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10415-20
• All: 17 reference(s)