Ptprf^tm1Wjh
Targeted Allele Detail

Summary

• Symbol: Ptprf^tm1Wjh
• Name: protein tyrosine phosphatase receptor type F; targeted mutation 1, Wiljan JAJ Hendriks
• MGI ID: MGI:2158762
• Synonyms: LAR-, LARdeltaP
• Gene: Ptprf Location: Chr4:118065410-118148602 bp, - strand Genetic Position: Chr4, 54.47 cM, cytoband C6-D1
• Alliance: Ptprf^tm1Wjh page

Craniofacial anomalies in Ptprf^tm1Wjh/Ptprf^tm1Wjh Ptprs^tm1Mtr/Ptprs^tm1Mtr double-mutant embryos

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42273
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the exons encoding the cytoplasmic tyrosine phosphatase domains. Northern blot analyses detected truncated but not wild-type transcripts in several tissues from homozygous mutant 3 month old male mice. Truncated protein was also detected on the surface of homozgyote thymocytes with reduced expression compared to endogenous protein. (J:42273, J:119456)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptprf Mutation: 100 strains or lines available

References

• Original: J:42273 Schaapveld RQ, et al., Impaired mammary gland development and function in mice lacking LAR receptor-like tyrosine phosphatase activity. Dev Biol. 1997 Aug 1;188(1):134-46
• All: 10 reference(s)