Il6^tm1Poli
Targeted Allele Detail

Summary

• Symbol: Il6^tm1Poli
• Name: interleukin 6; targeted mutation 1, Valeria Poli
• MGI ID: MGI:2158764
• Synonyms: IL-6-
• Gene: Il6 Location: Chr5:30218112-30224973 bp, + strand Genetic Position: Chr5, 15.7 cM
• Alliance: Il6^tm1Poli page

Il6^tm1Poli/Il6^tm1Poli mice exhibit increased susceptibility to Candida albicans infection

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:17249
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing exons 1, 2 and 3 was replaced with a neomycin selection cassette. Northern blot analysis on RNA derived from LPS-induced splenocytes of homozygous mice demonstrated that no detectable transcript was produced from this allele. ELISA assays confirmed that no detectable protein was produced in homozygous mice. (J:17249, J:47064)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il6 Mutation: 38 strains or lines available

References

• Original: J:17249 Poli V, et al., Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. EMBO J. 1994 Mar 1;13(5):1189-96
• All: 44 reference(s)