F3^tm1Jld
Targeted Allele Detail

Summary

• Symbol: F3^tm1Jld
• Name: coagulation factor III; targeted mutation 1, Jay L Degen
• MGI ID: MGI:2158778
• Synonyms: TF-
• Gene: F3 Location: Chr3:121517186-121528697 bp, + strand Genetic Position: Chr3, 52.94 cM
• Alliance: F3^tm1Jld page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33831
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An Hprt minigene replaced a 6.0 kb genomic fragment containing the proximal promoter region, the transcription start site, exons 1, 2 and part of 3. Reduced clotting activity in brain and lung microsome sections was shown in in heterozygous mice. (J:33831)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any F3 Mutation: 24 strains or lines available

References

• Original: J:33831 Bugge TH, et al., Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6258-63
• All: 2 reference(s)