Nos2^tm1Liew
Targeted Allele Detail

Summary

• Symbol: Nos2^tm1Liew
• Name: nitric oxide synthase 2, inducible; targeted mutation 1, Foo Y Liew
• MGI ID: MGI:2158787
• Synonyms: iNOS-
• Gene: Nos2 Location: Chr11:78811613-78851052 bp, + strand Genetic Position: Chr11, 46.74 cM
• Alliance: Nos2^tm1Liew page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:25755
• Parent Cell Line: CGR8 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Other
• Mutation details: A genomic rearrangement of the gene occurred, but the expected deletion of exons 1-5 did not occur by homologous recombination. An aberrant 4.5 kb mRNA was expressed from this allele, and western blot experiments on proteins derived from macrophages of homozygous mice confirmed that no detectable protein was made. (J:25755)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nos2 Mutation: 67 strains or lines available

References

• Original: J:25755 Wei XQ, et al., Altered immune responses in mice lacking inducible nitric oxide synthase. Nature. 1995 Jun 1;375(6530):408-11
• All: 11 reference(s)