Nos2^tm1Mrl
Targeted Allele Detail

Summary

• Symbol: Nos2^tm1Mrl
• Name: nitric oxide synthase 2, inducible; targeted mutation 1, Merck Research Laboratory
• MGI ID: MGI:2158791
• Synonyms: iNOS-, iNOS KO, NOS2-, Nos2^tm1Ntn
• Gene: Nos2 Location: Chr11:78811613-78851052 bp, + strand Genetic Position: Chr11, 46.74 cM
• Alliance: Nos2^tm1Mrl page

Renal tubular apoptosis, regeneration, glomerulosclerosis and glomerular thrombus formation in Nos1^tm1Plh/Nos1^tm1Plh Nos2^tm1Mrl/Nos2^tm1Mrl Nos3^tm1Plh/Nos3^tm1Plh mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:25511
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing 585 bp of the promoter and exons 1-4. Northern blot analysis on RNA derived from various tissues of homozygous mice demonstrated that no detectable transcript was produced from this allele. However, a transcript has been reported from sequence downstream from exon 4. (J:25511, J:53925)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	19 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Nos2 Mutation: 67 strains or lines available

References

• Original: J:25511 MacMicking JD, et al., Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase [published erratum appears in Cell 1995 Jun 30;81(7):following 1170]. Cell. 1995 May 19;81(4):641-50
• All: 155 reference(s)