Ptprd^tm1Yiw
Targeted Allele Detail

Summary

• Symbol: Ptprd^tm1Yiw
• Name: protein tyrosine phosphatase receptor type D; targeted mutation 1, Yoichiro Iwakura
• MGI ID: MGI:2158795
• Synonyms: PTPdelta, Ptprd-, RPTDdelta
• Gene: Ptprd Location: Chr4:75859475-78130198 bp, - strand Genetic Position: Chr4, 36.94 cM
• Alliance: Ptprd^tm1Yiw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63046
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced sequences encoding the first phosphatase signature motif. Northern blot and RT-PCR analyses did not detect mRNA containing the first PTP domain, but did detect a shorter mRNA in brain and kidney from homozygous mutant mice. (J:63046)

Expression

In Mice Carrying this Mutation:	58 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptprd Mutation: 121 strains or lines available

References

• Original: J:63046 Uetani N, et al., Impaired learning with enhanced hippocampal long-term potentiation in PTPdelta-deficient mice. EMBO J. 2000 Jun 15;19(12):2775-85
• All: 17 reference(s)