Fkbp1a^tm1Zuk
Targeted Allele Detail

Summary

• Symbol: Fkbp1a^tm1Zuk
• Name: FK506 binding protein 1a; targeted mutation 1, Martin M Matzuk
• MGI ID: MGI:2158807
• Synonyms: FKBP12^m1
• Gene: Fkbp1a Location: Chr2:151384403-151403611 bp, + strand Genetic Position: Chr2, 74.83 cM
• Alliance: Fkbp1a^tm1Zuk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45536
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An Hprt minigene replaced a genomic fragment containing exons 3 and 4, which encode domains required for protein activity. (J:45536)

Disease models

Expression

In Structures Affected by this Mutation:

16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fkbp1a Mutation: 14 strains or lines available

References

• Original: J:45536 Shou W, et al., Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12. Nature. 1998 Jan 29;391(6666):489-92
• All: 5 reference(s)