Thbdtm1Wlr
Targeted Allele Detail
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Symbol: |
Thbdtm1Wlr |
Name: |
thrombomodulin; targeted mutation 1, Harmut Weiler |
MGI ID: |
MGI:2158812 |
Synonyms: |
ThbdPro, TMP, TMPro |
Gene: |
Thbd Location: Chr2:148246391-148250108 bp, - strand Genetic Position: Chr2, 73.45 cM
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Alliance: |
Thbdtm1Wlr page
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Germline Transmission: |
Earliest citation of germline transmission:
J:47676
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Parent Cell Line: |
D3 (ES Cell)
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Strain of Origin: |
129S2/SvPas
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Allele Type: |
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Targeted |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: Point mutations were introduced into the gene that altered codon 387 from one encoding glutamate to one endcoding proline. A neomycin selection cassette was also inserted downstream of the polyadenylation site in the 3' end of the gene. Immunohistochemistry experiments confirmed that a mutant protein was expressed from this allele in an identical pattern to the wild-type protein (data not shown).
(J:47676)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Thbd Mutation: |
25 strains or lines available
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Original: |
J:47676 Weiler-Guettler H, et al., A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state. J Clin Invest. 1998 May 1;101(9):1983-91 |
All: |
23 reference(s) |
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