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Thbdtm1Wlr
Targeted Allele Detail
Summary
Symbol: Thbdtm1Wlr
Name: thrombomodulin; targeted mutation 1, Harmut Weiler
MGI ID: MGI:2158812
Synonyms: ThbdPro, TMP, TMPro
Gene: Thbd  Location: Chr2:148246391-148250108 bp, - strand  Genetic Position: Chr2, 73.45 cM
Alliance: Thbdtm1Wlr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:47676
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsPoint mutations were introduced into the gene that altered codon 387 from one encoding glutamate to one endcoding proline. A neomycin selection cassette was also inserted downstream of the polyadenylation site in the 3' end of the gene. Immunohistochemistry experiments confirmed that a mutant protein was expressed from this allele in an identical pattern to the wild-type protein (data not shown). (J:47676)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Thbd Mutation:  25 strains or lines available
References
Original:  J:47676 Weiler-Guettler H, et al., A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state. J Clin Invest. 1998 May 1;101(9):1983-91
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory