Thbd^tm2Rdr
Targeted Allele Detail

Summary

• Symbol: Thbd^tm2Rdr
• Name: thrombomodulin; targeted mutation 2, Robert D Rosenberg
• MGI ID: MGI:2158818
• Synonyms: Thbd^-, TM-lacZ, TM^lacZ, TMlacZ
• Gene: Thbd Location: Chr2:148246391-148250108 bp, - strand Genetic Position: Chr2, 73.45 cM
• Alliance: Thbd^tm2Rdr page

Venous and arterial thrombi and extravascular fibrinogen deposition in the lungs of Thbd^tm2Rdr/Thbd^tm2Wlr Tg(Tek-cre)1Ywa/0 mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74855
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ gene and neomycin selection cassette was inserted into the start codon of the gene. A hybrid mRNA molecule, consisting of 157 nucleotides of the endogenous 5' untranslated mRNA followed by the lacZ open reading frame, was transcribed from this allele. (J:71269, J:74855)

Expression

In Mice Carrying this Mutation:	49 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Thbd Mutation: 25 strains or lines available

References

• Original: J:74855 Weiler-Guettler H, et al., Targeting of transgene expression to the vascular endothelium of mice by homologous recombination at the thrombomodulin locus. Circ Res. 1996 Feb;78(2):180-7
• All: 12 reference(s)