Thbd^tm2Wlr
Targeted Allele Detail

Summary

• Symbol: Thbd^tm2Wlr
• Name: thrombomodulin; targeted mutation 2, Harmut Weiler
• MGI ID: MGI:2158819
• Synonyms: TM^Lox
• Gene: Thbd Location: Chr2:148246391-148250108 bp, - strand Genetic Position: Chr2, 73.45 cM
• Alliance: Thbd^tm2Wlr page

Cardiomegaly in Thbd^tm2Rdr/Thbd^tm2Wlr Tg(Tek-cre)1Ywa/0 mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71269
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted that flank the coding regions of the gene as well as an introduced neomycin selection cassette. These insertions have no effect on the normal function of the gene. (J:71269)

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Thbd Mutation: 25 strains or lines available

References

• Original: J:71269 Isermann B, et al., Endothelium-specific loss of murine thrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile-onset thrombosis. J Clin Invest. 2001 Aug;108(4):537-46
• All: 7 reference(s)