Man2a2^tm1Mfu
Targeted Allele Detail

Summary

• Symbol: Man2a2^tm1Mfu
• Name: mannosidase 2, alpha 2; targeted mutation 1, Michiko N Fukuda
• MGI ID: MGI:2158829
• Synonyms: MX-
• Gene: Man2a2 Location: Chr7:79998845-80021123 bp, - strand Genetic Position: Chr7, 45.65 cM, cytoband D2
• Alliance: Man2a2^tm1Mfu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73658
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 2, which contains the translation initiation site. Western blot analysis using polyclonal antibodies did not detect protein in testes from homozygous mutant mice. (J:73658)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Man2a2 Mutation: 54 strains or lines available

References

• Original: J:73658 Akama TO, et al., Germ cell survival through carbohydrate-mediated interaction with Sertoli cells. Science. 2002 Jan 4;295(5552):124-7
• All: 4 reference(s)