Cd8b1^tm1Wpfl
Targeted Allele Detail

Summary

• Symbol: Cd8b1^tm1Wpfl
• Name: CD8 subunit beta 1; targeted mutation 1, Wai-Ping Fung-Leung
• MGI ID: MGI:2158830
• Synonyms: CD8beta -
• Gene: Cd8b1 Location: Chr6:71299772-71314476 bp, + strand Genetic Position: Chr6, 32.14 cM
• Alliance: Cd8b1^tm1Wpfl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:19928
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection gene was inserted into exon 1, 7 nucleotides downstream from the translation start site. Flow cytometry experiments on cells derived from thymus, spleen and lymph nodes of homozygous mice confirmed that no protein was expressed from this allele. (J:19928)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd8b1 Mutation: 20 strains or lines available

References

• Original: J:19928 Fung-Leung WP, et al., Reduced thymic maturation but normal effector function of CD8+ T cells in CD8 beta gene-targeted mice. J Exp Med. 1994 Sep 1;180(3):959-67
• All: 1 reference(s)