Ercc1^tm1Dwm
Targeted Allele Detail

Summary

• Symbol: Ercc1^tm1Dwm
• Name: excision repair cross-complementing rodent repair deficiency, complementation group 1; targeted mutation 1, David W Melton
• MGI ID: MGI:2158940
• Synonyms: Ercc1-, ERCC-1 -
• Gene: Ercc1 Location: Chr7:19079016-19090449 bp, + strand Genetic Position: Chr7, 9.6 cM
• Alliance: Ercc1^tm1Dwm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:15422
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene was inserted into exon 5. Northern blot analysis on RNA derived from brain of homozygous mice demonstrated that no detectable transcript was produced from this allele. (J:15422)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ercc1 Mutation: 28 strains or lines available

References

• Original: J:15422 McWhir J, et al., Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning [see comments]. Nat Genet. 1993 Nov;5(3):217-24
• All: 11 reference(s)