Sema3a^tm1.1Tyag
Targeted Allele Detail

Summary

• Symbol: Sema3a^tm1.1Tyag
• Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A; targeted mutation 1.1, Takeshi Yagi
• MGI ID: MGI:2158944
• Synonyms: Sema3a^-, semaphorin III/D null
• Gene: Sema3a Location: Chr5:13175381-13652533 bp, + strand Genetic Position: Chr5, 4.31 cM
• Alliance: Sema3a^tm1.1Tyag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43443
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: This allele was generated from Sema3a^tm1Tyag by transient cre expression in TT-2 cells. Recombination produced three alleles, Sema3a^tm1.1Tyag, Sema3a^tm1.2Tyag and Sema3a^tm1.3Tyag. Sema3^tm1.1Tyag has had the first exon, including the initiation codon, deleted. (J:43443)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	62 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sema3a Mutation: 48 strains or lines available

Notes

Homozygous embryos are largely viable after birth but at 4 weeks after birth are about half the body weight of wild-type and have abnormalities in peripheral nerve projection.

References

• Original: J:43443 Taniguchi M, et al., Disruption of semaphorin III/D gene causes severe abnormality in peripheral nerve projection. Neuron. 1997 Sep;19(3):519-30
• All: 46 reference(s)