Ece1^tm1Reh
Targeted Allele Detail

Summary

• Symbol: Ece1^tm1Reh
• Name: endothelin converting enzyme 1; targeted mutation 1, Robert E Hammer
• MGI ID: MGI:2158947
• Synonyms: ECE-1 -
• Gene: Ece1 Location: Chr4:137589548-137692540 bp, + strand Genetic Position: Chr4, 70.02 cM
• Alliance: Ece1^tm1Reh page

Cardiac defects in Ece1^tm1Reh/Ece1^tm1Reh and Ece1^tm1Reh/Ece1^tm1Reh Ece2^tm1Ywa/Ece2^tm1Ywa embryos

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46640
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced an exon containing coding sequences upstream of the zinc-binding motif. Western blot analysis on membrane preparations of homozygous E17-19 embryos confirmed that no detectable encoded protein was produced from this allele. (J:46640)

Disease models

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	38 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ece1 Mutation: 137 strains or lines available

References

• Original: J:46640 Yanagisawa H, et al., Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene. Development. 1998 Mar;125(5):825-36
• All: 14 reference(s)