Oprm1^tm1Kff
Targeted Allele Detail

Summary

• Symbol: Oprm1^tm1Kff
• Name: opioid receptor, mu 1; targeted mutation 1, Brigitte L Kieffer
• MGI ID: MGI:2159000
• Synonyms: MOR-
• Gene: Oprm1 Location: Chr10:6708593-6988209 bp, + strand Genetic Position: Chr10, 1.85 cM, cytoband A2
• Alliance: Oprm1^tm1Kff page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36241
• Parent Cell Line: P1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 2. Binding assays on brain of homozygous animals confirmed that no functional protein was made from this allele. (J:36241)

Disease models

Expression

In Mice Carrying this Mutation:

1 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Oprm1 Mutation: 54 strains or lines available

References

• Original: J:36241 Matthes HW, et al., Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene [see comments]. Nature. 1996 Oct 31;383(6603):819-23
• All: 82 reference(s)