Anxa7^tm1Pll
Targeted Allele Detail

Summary

• Symbol: Anxa7^tm1Pll
• Name: annexin A7; targeted mutation 1, Harvey B Pollard
• MGI ID: MGI:2159005
• Synonyms: anx7 -
• Gene: Anxa7 Location: Chr14:20505344-20530009 bp, - strand Genetic Position: Chr14, 11.53 cM
• Alliance: Anxa7^tm1Pll page

Metastatic lymphosarcoma of the thymus in Anxa7^tm1Pll/Anxa7⁺ mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58572
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing exon 6. Western blot analysis on pancreatic tissue lysates of homozygous mice confirmed that levels of the encoded protein were reduced in heterozygotes compared to wild-type. (J:58572)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Anxa7^tm1Pll

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Anxa7 Mutation: 38 strains or lines available

References

• Original: J:58572 Srivastava M, et al., Defects in inositol 1,4,5-trisphosphate receptor expression, Ca(2+) signaling, and insulin secretion in the anx7(+/-) knockout mouse. Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13783-8
• All: 4 reference(s)