Anxa7^tm1Ngl
Targeted Allele Detail

Summary

• Symbol: Anxa7^tm1Ngl
• Name: annexin A7; targeted mutation 1, Angelika A Noegel
• MGI ID: MGI:2159006
• Synonyms: anxA7^-, Anxa7^-
• Gene: Anxa7 Location: Chr14:20505344-20530009 bp, - strand Genetic Position: Chr14, 11.53 cM
• Alliance: Anxa7^tm1Ngl page

Abnormal red blood cells in wild type and Anxa7^tm1Ngl/Anxa7^tm1Ngl mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:69979
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 8. Northern blot analysis on RNA derived from various tissues of homozygous mice demonstrated that aberrant transcripts were produced from this allele. Western blot analysis on lysates derived from brain, heart, pancreas and skeletal muscle confirmed that no detectable protein is made from this allele. (J:69979)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Anxa7 Mutation: 38 strains or lines available

References

• Original: J:69979 Herr C, et al., Loss of annexin A7 leads to alterations in frequency-induced shortening of isolated murine cardiomyocytes. Mol Cell Biol. 2001 Jul;21(13):4119-28
• All: 9 reference(s)