Neurod6^tm1Kan
Targeted Allele Detail

Summary

• Symbol: Neurod6^tm1Kan
• Name: neurogenic differentiation 6; targeted mutation 1, Klaus-Armin Nave
• MGI ID: MGI:2159008
• Synonyms: NEX -
• Gene: Neurod6 Location: Chr6:55654807-55658248 bp, - strand Genetic Position: Chr6, 27.53 cM
• Alliance: Neurod6^tm1Kan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45777
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing most of the coding region, including amino acids 53-337 encoding the bHLH domain. Northern blot analysis on brain RNA derived from P5 homozygous mice demonstrated that no detectable transcript is produced from this allele. (J:45777)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Neurod6 Mutation: 18 strains or lines available

References

• Original: J:45777 Schwab MH, et al., Neuronal basic helix-loop-helix proteins (NEX, neuroD, NDRF): spatiotemporal expression and targeted disruption of the NEX gene in transgenic mice. J Neurosci. 1998 Feb 15;18(4):1408-18
• All: 2 reference(s)