Neurog2^tm2Fgu
Targeted Allele Detail

Summary

• Symbol: Neurog2^tm2Fgu
• Name: neurogenin 2; targeted mutation 2, Francois Guillemot
• MGI ID: MGI:2159010
• Synonyms: Ngn2^-, Ngn2^KIlacZ, Ngn2^lacZ, Ngn2^lacZKI
• Gene: Neurog2 Location: Chr3:127426784-127429280 bp, + strand Genetic Position: Chr3, 56.54 cM, cytoband H1
• Alliance: Neurog2^tm2Fgu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59428
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-lacZ gene and loxP-flanked neomycin selection cassette replaced a genomic fragment containing most of the coding region of the gene. A beta-galactosidase protein is expressed from this allele under the control of the endogenous promoter. (J:59428)

Expression

In Mice Carrying this Mutation:	194 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Neurog2 Mutation: 18 strains or lines available

References

• Original: J:59428 Fode C, et al., A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons. Genes Dev. 2000 Jan 1;14(1):67-80
• All: 18 reference(s)