Neurog3^tm1Fgu
Targeted Allele Detail

Summary

• Symbol: Neurog3^tm1Fgu
• Name: neurogenin 3; targeted mutation 1, Francois Guillemot
• MGI ID: MGI:2159017
• Synonyms: ngn3 -, Ngn3^neo
• Gene: Neurog3 Location: Chr10:61968869-61970542 bp, + strand Genetic Position: Chr10, 32.35 cM, cytoband B4
• Alliance: Neurog3^tm1Fgu page

Loss of enteroendocrine cells in Neurog3^tm1Fgu/Neurog3^tm3.1Ggr Tg(Vil1-cre)20Syr/0 and Neurog3^tm3.1Ggr/Neurog3^tm3.1Ggr Tg(Vil1-cre)20Syr/0 mice

Show the 6 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60642
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a 628 bp DNA segment containing 468 bp of coding sequence, including sequences corresponding to the bHLH domain.

Expression

In Mice Carrying this Mutation:	33 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Neurog3 Mutation: 19 strains or lines available

References

• Original: J:60642 Gradwohl G, et al., neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1607-11
• All: 18 reference(s)