Cnga2^tm1Gvr
Targeted Allele Detail

Summary

• Symbol: Cnga2^tm1Gvr
• Name: cyclic nucleotide gated channel alpha 2; targeted mutation 1, Gabriele V Ronnett
• MGI ID: MGI:2159208
• Synonyms: OCNC1 -
• Gene: Cnga2 Location: ChrX:71035455-71053824 bp, + strand Genetic Position: ChrX, 37.15 cM, cytoband A6
• Alliance: Cnga2^tm1Gvr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74854
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced nucleotides 1416-2164, which encode the cyclic nucleotide binding domain. In situ hybridization and RT-PCR analysis on olfactory epithelium of homozygous mice confirmed that no detectable transcript is produced from this allele. (J:74854)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cnga2 Mutation: 17 strains or lines available

References

• Original: J:74854 Parent A, et al., Synaptic transmission and hippocampal long-term potentiation in olfactory cyclic nucleotide-gated channel type 1 null mouse. J Neurophysiol. 1998 Jun;79(6):3295-301
• All: 5 reference(s)