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Nr0b1tm1Lja
Targeted Allele Detail
Summary
Symbol: Nr0b1tm1Lja
Name: nuclear receptor subfamily 0, group B, member 1; targeted mutation 1, J Larry Jameson
MGI ID: MGI:2159305
Synonyms: Ahchflox2, B6-DAX1, Dax1flox
Gene: Nr0b1  Location: ChrX:85235381-85239553 bp, + strand  Genetic Position: ChrX, 39.67 cM
Alliance: Nr0b1tm1Lja page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:51292
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed PGK-neomycin resistance cassette was inserted downstream of exon 2 and a third loxP site was inserted upstream of the splice acceptor signal in exon 2. (J:51292)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Nr0b1 Mutation:  9 strains or lines available
References
Original:  J:51292 Yu RN, et al., Role of Ahch in gonadal development and gametogenesis [see comments]. Nat Genet. 1998 Dec;20(4):353-7
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory