Drd1^tm1Stl
Targeted Allele Detail

Summary

• Symbol: Drd1^tm1Stl
• Name: dopamine receptor D1; targeted mutation 1, Susumu Tonegawa
• MGI ID: MGI:2159306
• Synonyms: D1^-, D1R^-
• Gene: Drd1 Location: Chr13:54205202-54209677 bp, - strand Genetic Position: Chr13, 28.4 cM
• Alliance: Drd1^tm1Stl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:21603
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A PGK-neomycin based targeting vector replaced the 95% of the coding region. (J:21603)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Drd1 Mutation: 70 strains or lines available

References

• Original: J:21603 Xu M, et al., Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses. Cell. 1994 Nov 18;79(4):729-42
• All: 29 reference(s)