Wasl^tm1.1Cgn
Targeted Allele Detail

Summary

• Symbol: Wasl^tm1.1Cgn
• Name: WASP like actin nucleation promoting factor; targeted mutation 1.1, University of Cologne
• MGI ID: MGI:2159338
• Synonyms: N-WASP^del, Wasl^tm1.1Wehl
• Gene: Wasl Location: Chr6:24613804-24665008 bp, - strand Genetic Position: Chr6, 11.28 cM, cytoband A3
• Alliance: Wasl^tm1.1Cgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73609
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele is a derivative of Wasl^tm1Wehl. Cre-mediated recombination in vivo removed exons 6-9 in the germline, eliminating the effector domains and leaving a single loxP site in place of the deleted sequence. The authors predict that splicing exon 5 to the remaining exon 10 would create a premature stop codon. (J:73609)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wasl Mutation: 39 strains or lines available

References

• Original: J:73609 Lommel S, et al., Actin pedestal formation by enteropathogenic Escherichia coli and intracellular motility of Shigella flexneri are abolished in N-WASP-defective cells. EMBO Rep. 2001 Sep;2(9):850-7
• All: 1 reference(s)